If so, the data provided is not processed in the Brief Profile. This section summarises the values related to short–term toxicity to fish from all registered dossiers for the substance. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. The quality and correctness of the information remains the responsibility of the data submitter. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. This section summarises the melting and freezing point values from all registered dossiers for the substance. Thus, the smaller the value of pKa, the stronger the acid. The results of matching substance classifications are displayed in percentages of the total number of notifications. Suspendisse porttitor leo quis purus porttitor posuere sit amet sit amet nunc. Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance. Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. No or insufficient data available at present, Hazard related to composition of atmosphere identified, No potential to cause toxic effects if accumulated (in higher organisms) via the food chain, bw/day (mg/kg bw/day; mg/kg bw/day; mg/kg bw/day), DMEL (Derived Minimum Effect Level) - not included for short–term effects, Insufficient data available (further information necessary), Hazard unknown (no further information necessary), Hazard unknown but no further hazard information necessary as no exposure expected, ‘No DNEL required: short term exposure controlled by conditions for long-term’ is added, Hamster (combine hamster, Armenian; hamster, Chinese and hamster, Syrian), No adverse effect observed (not irritating), Adverse effect observed (irreversible damage), mg/kg bw/day (nominal/actual dose received), See ‘Study results oral: Prioritization by test species’, mg/L air (combining mg/L air, mg/L air (nominal), mg/L air (analytical), mg/m³ air, mg/m³ air (nominal), mg/m³ air (analytical)), ppm (combine ppm, ppm (nominal), ppm (analytical), mg/kg bw/day (actual dose received), mg/kg bw/day (combining mg/kg bw/day (nominal), mg/kg bw/day (actual dose received) and mg/kg bw/day), mg/cm² per day (combining mg/cm² per day, mg/cm² per day (nominal), mg/cm² per day (analytical)), No study available / no study available (further information necessary). Fusce eget lorem sed purus tempus blandit. Analytical Chemistry 1959 , 31 (8) , 1326-1331. If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method). Typically phthalate esters are prepared from the widely available phthalic anhydride. Phthalic acid has applications in the preparation of phthalate ester plasticizers. Readily biodegradable but failing the 10-day window. Under specific conditions, a registrant can claim confidentiality of their identity. Examples include recommended measures on fire-fighting, transport, recycling and disposal. Based on given acidity constants (pK a values) the pH of organic acids for 1, 10, and 100 mmol/L are calculated.The results are listed in the following tables (valid for standard conditions 25°C, 1 atm):. This section searches three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). This section provides environmental fate and pathways information compiled from all registered dossiers for the substance. The content is subject to change without prior notice. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. d-Tartaric Acid – C 4 H 6 O 6 3.0, 4.4 2.0-5.4 . If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance. BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. If so, the data provided is not processed for the Brief Profile. [, Takeuchi S, Iida M, Kobayashi S, Jin K, Matsuda T, Kojima H: Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor. This Brief Profile is covered by the ECHA Legal Disclaimer. These study results can however be consulted when opening the source data. Data is generally displayed in milligrams per kilogram, per bodyweight per day. Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species: See ‘Summary effect on fertility oral route’. level’ as the dose descriptor. Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. This website uses cookies to ensure you get the best experience on our websites. The POPs regulatory processes identified for the Brief Profile are: Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). Contact us to learn more about these and other features. Ka1= 1.2x 10^-3, and Ka2 = 3.9 x 10^-6. This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance. Nat Rev Drug Discov. The information provided in the free-text fields is not published in the Brief Profiles. Potassium Bipthalate . Displayed is the most conservative of the prioritised value(s). (NTP, 1992). Guidance on the safe use of the substance provided by manufacturers and importers of this substance. Pesticide properties for Phthalic acid, including approvals, environmental fate, eco-toxicity and human health issues pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. According to the classification provided by companies to ECHA in REACH registrations this substance causes serious eye damage. Applicant’s summary and conclusion – Interpretation of results provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: Note: Registrants can also select ‘other’ as picklist option for describing the biodegradation values of the substance in water. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. The brief profile is based on non-confidential data contained in ECHA’s databases at the time of generation. Autoflammability / Self-ignition at 101 325 Pa provides substance information on the substance’s self-ignition temperature in °C at a pressure of 101 325 Pa. Ask Question + 100. Data is generally standardised and displayed in milligram per litre/cubic metre. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method). Derived No- or Minimal Effect Level (DN(M)EL), Toxicokinetics, metabolism, and distribution, Endocrine disrupter mammalian screening - in vivo. H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Harmonised classifications (√ - check mark). If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. Values are generally displayed in milligram per litre. Biodegradation in water - screening tests, Biodegradation in water & sediment - simulation tests. PBT properties are derived from REACH registered substances dossiers. Relative density at 20 °C provides information on the substance relative density at 20 °C. The solubility of phthalic acid in water is 0.54 g/100 mL at 14°C and 18 g/100 mL at 99°C.What is the smallest volume of boiling water that should be used to recrystallize 600 mg of phthalic acid … Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. While it is present in the final substance, it was not intentionally added. Post navigation ← Entropy Calculation for Ideal Gas Elements General Physical Properties : Atomic Size | Melting point | Boiling point → Applicant’s summary and conclusion – Interpretation of results (inhalation). EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. Values are generally displayed in milligrams per kilogram (dry weight). References 1. The availability of additional data beyond the five results displayed is indicated by (…). If so, the data provided is not processed for the Brief Profile. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Perrin, D. D., Dissociation Constants of Organic Bases in Aqueous Solution, Butterworths, London, 1965; Supplement, 1972. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Reduction of phthalic acid with sodium amalgam in the presence of water gives the 1,3-cyclohexadiene derivative. This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C. Data is generally standardised and displayed in in milligram per kilo of food. E5: Acid Dissociation Constants of Organics Last updated; Save as PDF Page ID 6647; … For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. For most weak acids, pKa ranges from 2 to 14. Values provided in ppb and Vol% are provided separately. After evaluation, proposals may be made for further regulatory action regarding the substance. The % is based on count of values provided. EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre. Note: Registrants can also select ‘other’ as the type of Henry’s law constant. Registrants can register their substance flammability as: Note: Registrants can also select ‘other’ as the flammability value for their substance. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method).Relative density provides substance information on the relatively density (measurement units are not processed for relative density) at a temperature measured in Celsius (°C). The availability of additional data beyond the five results displayed is indicated by (…) icon. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. For substance’s physical state at 20°C and 1 013 hPa, registrants can classify their substance as: For substance’s form, registrants can classify their substance as: For substance’s odour, registrants can classify their substance as: For substance’s type, registrants can classify their substance as: Summary data is collected from the endpoint summary(ies) provided by registrants of REACH dossiers. The substance identifiers – if available and not claimed confidential – displayed in the ’Substance identity’ section of the Brief Profile are: In addition, information on the type of substance, origin, number and type of registered compositions and other places where the substance is listed are displayed in this section. pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 10:52. Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure. The data presented in these sections has been cleaned to remove names of one character or less, or names which consist solely of punctuation or numerical characters. Proin faucibus mollis lectus ut fermentum. All data apply to dilute aqueous solutions and are presented in the form of pKa, which is the negative of the logarithm of the acid dissociation constant Ka. Nat Rev Drug Discov. If such information is available in ECHA’s database and is it not claimed confidential, the molecular formula and molecular structure will be displayed here. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. If information on guidance on safe use is available in REACH registered dossiers, a link is displayed. EC Inventory, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances. 2004 Feb;378(3):664-9. Impurities or additives: When a specific critical property is associated with compositions with impurities and/or additives, the respective critical property icon has a * associated. The PIC regulatory processes identified for the Brief Profile are: The ’About this substance’ section provides an overview of the volume in which this substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter. The CAS number is the substance numerical identifier assigned by the Chemical Abstract Service, a division of the American Chemical Society, to substances registered in the CAS registry database. Ionic strength 0 0.1 MName Structure pK a K a pK a —— B(OH) 3 Bromoacetic acid BrCH 2CO 2H 2.902 1.25 10 3 2.71 CH 3CH 2CH 2CO 2H 4.818 1.52 10 5 4.62 Butylamine CH 3CH 2CH 2CH 2NH 10.640 2.29 10 11 10.66 Chloroacetic acid ClCH 2CO 2H 2.865 1.36 10 3 2.69 3-Chloropropanoic acid ClCH Dipotassium phthalate. EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. Vestibulum tincidunt ultricies libero quis mollis. Registrants can register their substance’s flammability as: This section summarises the explosiveness values from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). 1 000 g will be displayed as 1 kg. Phthalic acid, also called 1, 2-benzenedicarboxylic Acid, colourless, crystalline organic compound ordinarily produced and sold in the form of its anhydride. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. If more than one value is available, results are displayed as concatenated distinct values, ordered from most to least commonly provided, with the percentage of provided values appended. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. Thirdly the display of data is prioritised by units. The pKa's for phthalic acid (the 1,2-dicarboxylic acid of benzene) are pKa1 = 2.98 and pKa2 = 5.28. Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. If there are additives and impurities relevant for the substance classification, these are also indicated. Values are generally displayed in milligram per kilo soil (dry weight). Phys. Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. Pesticide properties for Phthalic acid, including approvals, environmental fate, eco-toxicity and human health issues Information on the most sensitive study can be provided by the registrants as: Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers). More detailed information is available in the dossiers. Additionally, if registrants select ‘other’ as a unit of measure for pressure, the measurement conditions (and therefore the study results) cannot be processed in the Brief Profile. This information has not been reviewed or verified by ECHA, and may change without prior notice. Dermal route provides substance information on the substance’s acute toxicity via the dermal route. Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C. Please note: The icons in this section are only meant as visual indicators to help communicate information about the abovementioned critical properties. This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance. Michael Diamantoglou, Gerhard Meyer, "Process for the production of water-insoluble fibers of cellulose monoesters of maleic acid, succinic acid and phthalic acid, having an extremely high absorbability for water and physiological liquids." Data from all dossiers registered for the same substance is used in the summarisation and aggregation process, as it is presumed that all data submitted by the registrants is relevant for the substance being registered. However, substance notifications in the Brief Profile are aggregated independently of the impurities and additives. This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. The Agency thus cannot guarantee the correctness of the information displayed. It may, for example, originate from the starting materials or be the result of secondary or incomplete reactions during the production process. See ‘Summary effect on fertility oral route’, except: This section displays the values related to neurotoxicity from all registered dossiers for the substance. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Registrants can identify the origin of their substance as being: If more than one type of substance is registered, both types will be displayed. Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. Applicant’s summary and conclusion – Interpretation of results. For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. Note: Registrants can also select ‘other’ as the picklist conclusion. Applicant’s summary and conclusion – Interpretation of results (dermal). Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight). Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’. The Agency thus cannot guarantee the correctness of the information displayed. Data is generally standardised and the displayed in milligram per litre or molar per litre. Data is generally standardised and displayed in milligram per kilo soil (dry weight). V.Care Service This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. The dissociation constant and pKa are given below the graphic aquatic plants ( other algae! 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